| abstract |
An agent selected from A / B-cis-furostane, furostane, spirostane and spirostene steroidal sapogenins and their ester, ether, ketone and glycolated forms thereof is used to induce self-regulating homeostasis of neurotrophic factors (NF), for example BDNF and / or GDNF, NF, with limited and manageable side effects in a subject by modulating NF in a non-toxic way in homeostatic regulation. An effective amount of at least one such agent is administered to a subject, in particular in the treatment or prevention of a number of NF-mediated disorders, especially neurological, psychiatric, inflammatory, allergic, immune and neoplastic disorders, and in the restoration or normalization of neuronal and other functions, or in relation to any damaged or abnormal tissue, including promoting the healing of tissue (e.g. skin, bone, eyes and muscles) and the overall health of the skin, bone, eyes and muscles. In FIG. Figure 1 shows the restorative effect of smilagenin on MMP-induced neuronal damage to rat primary dopaminergic neurons. Data are mean ± ST. about. average, n = 1-4 crops per group, equivalent to 4-230 fields. Statistical analysis was performed using a one-way ANOVA followed by the Fisher a posteriori test (#### = p <0.001, ## = p <0.01 compared to one MMP). |