abstract |
The present invention relates to new peptides, selective agonists of the corticotropin-releasing hormone type 2 (CRHR2) and compositions containing them for treatment, reducing the intensity of manifestation or slowing the development of pathological conditions of the cardiovascular system, including, among other things, heart failure. The new agonist peptide preferably contains modifications including pegylated peptides. In addition, the present invention relates to methods for treating and preventing diseases or disorders mediated by CRHR2 activity. |