| abstract |
The present invention relates to new compounds corresponding to the formula I, in which the definitions of W, W, W, W, W, B, X, X, X, X, X, E, and L are given in the description; the compounds of the present invention are positive allosteric modulators (enhancers) of subtype B gamma-aminobutyric acid receptors (GABA), which can be used in methods of treating or preventing diseases or disorders, including the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive impairment , spasticity and rigidity of skeletal muscles, damage to the spinal cord, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and addiction to cocaine and nicotine, panic disorder, post-traumatic stress disorders, urgent urinary incontinence, gastroesophageal reflux disease, temporary relaxation of the lower esophageal sphincter, functional gastrointestinal disorders and irritable bowel syndrome. |