| abstract |
4-amino-1 - ((2R, 3S, 4S, 5R) -5-azido-4-hydroxy-5-hydroxymethyl-3-methyltetrahydrofuran-2-yl) -1H-pyrimidin-2-one (22) is hepatitis C virus polymerase inhibitor (HCV / HCV). Also disclosed are compositions and methods for inhibiting HCV and treatment of diseases mediated by HCV, methods for the manufacture of compounds and synthetic intermediates used in the implementation of the method. |