| abstract |
The compounds of formula (I), their salts, N-oxides, hydrates and solvates are histone deacetylase inhibitors and are useful in the treatment of diseases associated with cell proliferation, including cancer, when Q, V and W are independently —N = or —C =, B denotes a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6), where the bond marked * is attached to the ring containing Q, V and W, through - [Linker1] - and the connection marked ** is connected to A through - [Linker2] -; A denotes a possibly substituted mono-, bi- or tricyclic carbocyclic or heterocyclic ring system; - [Linker1] - and - [Linker2] -, independently, represent a bond or a divalent linker radical, and R is (a) a radical of the formula RRCHNH-Y-L-X- (CH) - or (b) a radical of the formula R-L-Y- (CH) -. |