| abstract |
The present invention provides compounds of formula (I) or their stereoisomers, tautomers, pharmaceutically acceptable salts or solvate forms, wherein the variables A, L, M and R are defined herein. The compounds of formula (I) are selective cascade coagulation serine protease enzyme inhibitors and / or contact activation system; for example, thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and / or plasma kallikreins. This is especially true for compounds that are selective inhibitors of factor XIa. The present invention also relates to pharmaceutical compositions containing these compounds, and to methods of treating thrombembolic and / or inflammatory disorders using them. |