http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-200800640-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-00 |
| filingDate | 2006-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-200800640-A1 |
| titleOfInvention | QUINOLINES AND THEIR THERAPEUTIC APPLICATION |
| abstract | The compounds of formula [1] are CRTH2 antagonists useful in the treatment of conditions having an inflammatory component where: R, R, R, R and R independently represent a hydrogen atom, C-C1-6alkyl, C-Fluoroalkyl, cyclopropyl, halogen, -S (O) R, -SONRR, -NRR, -NRC (O) R, -COR, -C (O) NRR, -C (O) R, -NO, -CN or the group -OR; where each R independently is C-C1-6alkyl, C-Fluoroalkyl, cycloalkyl, aryl or heteroaryl; R, R are independently C 1-6 alkyl, C 1-6 fluoroalkyl, cycloalkyl, cycloalkyl- (C 1-6 alkyl) -, aryl, heteroaryl or a hydrogen atom; R 1 represents a hydrogen atom, C 1 -C 6alkyl, C 1 -Fluoroalkyl, cycloalkyl, cycloalkyl- (C-1-6alkyl) - or the group-SOR; A represents —CHR—, —C (O) -, —S (O) -, —O— or —NR—, where n is an integer from 0-2 and R represents a hydrogen atom, a C-C1-6alkyl or C -Fluoroalkyl group; B is a direct bond or a divalent radical selected from —CH—, —CHCH—, —CHR—, —CRR—, —CHCHR—, —CHCRR—, —CHRCHR— and divalent radicals of the formula - (CRR) —Z—, where Z is attached to a ring bearing R, R and R; where R is C 1-6 alkyl, cyclopropyl, C 1-4 fluoroalkyl; R 1 is methyl or fluoromethyl; p is independently 1 or 2; and Z is —O—, —NH— or —S (O) -, where n is an integer from 0-2; X represents a carboxylic acid group, tetrazole, 3-hydroxyisoxazole, hydroxamic acid group, phosphinate, phosphonate, phosphonamide or a sulfonic acid group, or a group of the formula C (= O) NHSOR or SONHC (= O) R; and Y represents an aryl, heteroaryl, aryl-fused heterocycloalkyl, heteroaryl-fused cycloalkyl, heteroaryl-fused heterocycloalkyl or aryl-fused cycloalkyl group. |
| priorityDate | 2005-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.