| titleOfInvention |
NEW DERIVATIVES 2,4-DIANILINOPIRIMIDINES, THEIR PRODUCTION, MEDICINES, PHARMACEUTICAL COMPOSITIONS, CONTAINING INDICATED DERIVATIVES, AND THEIR APPLICATION, IN PARTICULAR, AS THE PROTECTIVE. |
| abstract |
The invention relates to products of formula (I) in which R2, R3 and R4 denote one halogen atom and the others denote hydrogen, halogen, alkyl or alkoxy; R5 is hydrogen or halogen; R1 is hydrogen, cycloalkyl, alkyl, alkenyl or alkynyl, all optionally substituted; A is a single bond or a radical βCH β CO β NR6β, where R6 is selected from the values of R1; moreover, the cycle containing Y (or cycle (Y)) consists of 4-8 links and Y denotes O, S, SO, SO, N-R7 (and cycle (Y) may include a carbon bridge), C = O or dioxolane, CF, CH-OR8, CH-NR8R9; R7 is hydrogen, cycloalkyl, alkyl, CH-alkenyl or CH-alkynyl optionally substituted; R8 is hydrogen, alkyl, cycloalkyl or heterocycloalkyl optionally substituted, which products are in all possible isomeric forms, as well as their salts, as medicaments, in particular as IKK inhibitors. |