| abstract |
GLP-2 analogues are described, including one or more substituents compared to [hGly2] GLP-2, with improved in vivo biological activity and / or improved chemical stability, assessed by in vitro stability analysis. In particular, the preferred GLP-2 analogs described herein include substituents in one or more positions 8, 16, 24 and / or 28 wild-type sequence GLP-2, optionally in combination with additional substituents in position 2 (as indicated in the introduction) and in one or more positions 3, 5, 7, 10, and 11 and / or the removal of one or more amino acids 31-33 and / or attachment to the N-terminus or C-terminus of the stabilizing peptide sequence. Analogs are particularly useful for the prevention or treatment of diseases of the gastrointestinal tract and to reduce the side effects of chemotherapy. |