| abstract |
New methods for treating or reducing the likelihood of vaginal dysfunctions, in particular vaginal dryness and dyspareunia, leading to sexual dysfunction and decreased sexual desire and activity, in susceptible warm-blooded animals, including humans, that include the introduction of a sex steroid precursor. In particular, the additional administration of estrogen or a selective modulator of estrogen receptors is disclosed, in particular selected from the group consisting of raloxifene, arzoxifene, tamoxifen, droloxifene, lodoxifene, GW-5638, TSE-424, ERA-923 and lazofoxifene, more preferably compounds having general structure according to formula I, for medical treatment and / or inhibition of the development of some of the above diseases. Pharmaceutical compositions for administering the active ingredients and kits useful for the invention are also disclosed. |