| abstract |
Compounds of formula (I) in which R and R are the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; R 1 is hydrogen or a substituent of an aryl group, or R 1 is a solid support, optionally attached via a spacer; Z represents an oxygen atom, a sulfur atom or NR; Y represents an oxygen atom, a sulfur atom or NR; where R and R, which may be the same or different, are hydrogen, optionally substituted alkyl containing 1-6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted β-phenylethyl; and one of Xi X is a nitrogen atom, and the other of Xi X is a nitrogen atom or CR, where R represents hydrogen or an aryl group substituent, is used for affinity binding of a prion protein. |