| abstract |
The present invention is directed to certain hydroisoindoline compounds of the formula 1, which are useful as antagonists of the neurokinin-1 receptor (NK-1) and tachykinin inhibitors and, in particular, substance P. The invention also relates to pharmaceutical preparations containing these compounds as active ingredients , and the use of these compounds and their preparations for the treatment of certain disorders, including vomiting, urinary incontinence, depression and anxiety. |