| abstract |
(where n is an integer from 0 to 3; R represents a substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group or a substituted or unsubstituted aromatic heterocyclic group; R represents a halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alicyclic heterocyclic group, substituted or unsubstituted aromatic heterocyclic group, -COR or the like; R and R may be the same or different, and each of them represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, -COR or the like). For example, antagonists of an Aadenosine receptor are provided containing, as an active ingredient, a thiazole derivative represented by the general formula (I), or a pharmaceutically acceptable salt thereof and the like. |