http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-200501042-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-200501042-A1 |
| titleOfInvention | A METHOD FOR OBTAINING RACEMIC CYTALOPRAMDIOL AND / OR S- OR R-CYTALOPRAMDIOLS AND APPLICATION OF DIOL DATA FOR OBTAINING RACEMATIC CYTAL PROMOTION, R-CYTAL PREMIUM AND / OR S-CITO TI AND TI. |
| abstract | Subsequently, citalopramdiol means 4- [4- (dimethylamino) -1- (4-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) benzonitrile as the free base and / or acid addition salt. The invention relates to a method for producing racemic citalopramdiol and / or R- or S-citalopramdiol, comprising separating a non-racemic mixture of R- and S-citalopramdiol containing more than 50% of one enantiomer into a fraction enriched in R- or S-citalopramdiol, and a fraction containing RS-citalopramdiol, in which the ratio of R-citalopramdiol: S-citalopramdiol is 1: 1 or closer to 1: 1 than in the original mixture. The method is characterized in that (i) RS-citalopramdiol is precipitated from a solution of the initial non-racemic mixture, or R- or S-citalopramdiol is dissolved in a solvent from the initial non-racemic mixture, while leaving the remainder of RS-citalopramdiol, and (ii) the resulting residue / the precipitate is separated from the final liquid phase with the subsequent implementation of optional repeated steps of recrystallization, purification, isolation and conversion between the free base and salts. The invention also relates to a method for producing RS-citalopram, S-citalopram or R-citalopram (all in the form of a free base and / or an acid additive salt), including the above method followed by ring closure. The international application was published together with an international search report . |
| priorityDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.