abstract |
The present invention relates to methods and compositions containing compounds that treat physiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block the glycated protein-induced induction of a signal associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit the proliferation of smooth muscle cells by modulating heparan sulfate proteoglycans, such as perlecan. The present invention further relates to the use of compounds for the treatment of vascular occlusive conditions characterized by smooth muscle proliferation, such as restenosis and atherosclerosis. The international search report was published 2003.12.11. |