| abstract |
A pharmaceutical composition comprising two components is described: (a) a first component containing atorvastatin granulate or its pharmaceutically acceptable salts and a carrier comprising an alkalizing agent that creates a pH above 5, and (b) a second component containing amlodipine or its pharmaceutically acceptable salts the carrier, excluding the alkalinizing agent, which creates a pH above 5, where the two components are combined to form the final composition for the solid dosage form, and also describes how to obtain these compositions, burs containing such compositions, and a method of treating angina pectoris, atherosclerosis, concomitant hypertension and hyperlipidemia and / or hypercholesterolemia, and symptoms of the risk of heart disease using an effective amount of this pharmaceutical composition. |