http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-200300513-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 |
| filingDate | 2001-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-200300513-A1 |
| titleOfInvention | METHOD OF OBTAINING IOPAMIDOL AND NEW INTERMEDIATE CONNECTIONS RECEIVED IN THIS METHOD |
| abstract | The method of obtaining (S) -N, N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2,4,6-triiodo-1, 3-benzenedicarboxamide (iopamidol), starting from 5-amino-N, N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl] -2,4,6-triiodo-1,3-benzenedicarboxamide (II), and said method includes a) introducing a compound of formula (II) in reaction with a suitable protective agent to form a compound of formula (III), in which -R is a group of formula A or B, in which R is a hydrogen atom, C 1 -C or linear or branched alkoxy group, R is a hydrogen atom, C-linear or branched the n-alkoxy group and R is a C-linear or branched alkyl group, a trifluoromethyl or trichloromethyl group; b) acylation of the amino group in position 5 of the intermediate of formula (III) by reaction with (S) -2- (acetyloxy) propanoyl chloride to form a compound of formula (IV) in which R is the radical described above; and c) removing all acyl groups present in the compound of formula (IV) in an alkaline medium, with preliminary cleavage of the cyclic protection of the hydroxyl groups of the carboxamide substituents in an acidic medium, if R is a group of the formula A. The invention also relates to new intermediate compounds of the formulas (III ) and (IV), in which -R - Group A. The international application was published along with the international search report. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.