| abstract |
The present invention relates to β-adrenergic receptor agonists of structural formula (I), wherein Ar is pyridyl, oxazolyl, thiazolyl, or phenyl; Is a 5- or 6-membered heterocycle; X represents a direct bond or oxygen; and Y is a direct bond, alkylene, OCH, CHO or oxygen; their stereoisomers and prodrugs and pharmaceutically acceptable salts of these compounds, stereoisomers and prodrugs. In addition, in accordance with the present invention, intermediates useful in the preparation of compounds of formula (I) and combinations of compounds of formula (I), their stereoisomers and prodrugs and pharmaceutically acceptable salts of these compounds, stereoisomers and prodrugs with anti-obesity agents are proposed. The international application has been published along with an international search report. |