| abstract |
The compounds of formula (I), where R, R and R such, as defined above, which are inhibitors of enzymes of protein kinases, such as Janus kinase 3, and as such are useful in therapy as immunodepressive agents for organ transplantation, xenotransplantation, lupus, multiple sclerosis, rheumatoid arthritis , psoriasis, type I diabetes and complications of diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, nonspecific ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases. The international search even was published on 2001.11.22. |