| abstract |
The present invention relates to the sulfonamide derivatives of the formula (I), in particular to their use as pharmaceutically active compounds, as well as to pharmaceutical compositions containing such sulfonamide derivatives. These sulfonamide derivatives are effective modulators of JNK signaling pathways, in particular, they are effective and selective inhibitors of JNK2 and 3. The present invention further relates to new sulfonamide derivatives, as well as to methods for their preparation. Compounds of formula (I) of the present invention that are acceptable pharmaceutical agents include those in which Ar and Ar are independently substituted or unsubstituted aryl or heteroaryl groups, X is O or S, preferably O; R 2 is hydrogen or a C 1 –C 6 -alkyl group, or R forms a substituted or unsubstituted 5–6 membered saturated or unsaturated ring with Ar; n means an integer from 0 to 5, preferably 1-3 and most preferably 1; Y in formula (I) means an unsubstituted or substituted 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom the sulfonamide. The international application was published with the international search report. |