| abstract |
The present invention relates to compounds of the general formula (I) or to its pharmaceutically acceptable salts, where W, T, Y, X, Q, R, R, and R are defined herein. The present invention also relates to compounds of formula (I), depicted above, in which Y is —NH—; T is (2S, 3S) -2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S) -2-phenylpiperidin-3-yl can optionally be replaced by fluorine; Q is oxygen and is bonded to a carbon atom by a double bond, X is methoxy or ethoxy, R is hydrogen, methyl or halogen-C-C1-6 alkyl, W is methylene, ethylene or vinylene; R 5 and R 10 are independently hydrogen or methyl, or one of R 3 or R 5 may be hydroxy when W is ethylene, R 8 and R 8 are methyl, when W is methylene, and R 8 and R 8 are hydrogen, and W is vinyl. The present invention also relates to methods of treating various diseases of the CNS and other diseases in which these compounds are used and their pharmaceutical compositions. The international application was published together with an international search report. |