| abstract |
This invention relates to sorbitol dehydrogenase inhibiting compounds of the general formula (I), where R, R and R are as defined in the application materials. The present invention also relates to pharmaceutical compositions containing these compounds, and to methods for treating or preventing diabetic complications, in particular diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy, in which such compounds are administered to a mammal suffering from diabetes and therefore to a mammal suffering from diabetes and therefore. risk of developing such complications. This invention also relates to pharmaceutical compositions comprising a combination of a compound of formula (I) of this invention with an aldose reductase inhibitor, and methods for treating or preventing diabetic complications using such compositions. This invention also relates to pharmaceutical compositions comprising a combination of a compound of formula (I) of this invention with an NHE-1 inhibitor (sodium-hydrogen ion exchange), and to methods for treating cardiomyopathy and other heart related problems using such compositions. This invention also relates to certain intermediates used in the synthesis of compounds of formula (I), and to methods for producing these intermediates. The international application was published together with an international search report. |