| abstract |
New S-nitrosothiol derivatives of penicillamine or glutathione and their pharmaceutically acceptable salts, which correspond to the following general formula (I) in which A and B are phenyl groups or together form a residue -CH-Q-CH-, forming a six-membered ring, in which Q is an oxygen or sulfur atom, or an NR group in which R is hydrogen or an alkyl group CC; R is an acyl residue which may be an aliphatic acyl group C — C or a glutamic acid residue linked through its non-amino acid carboxyl; R is a hydroxyl group or glycine residue linked through its peptide bond; provided that when R is an aliphatic acyl residue, then R is a hydroxyl group, and when R is a glutamic acid residue, then R is a glycine residue. These new compounds have vasodilating activity and inhibit platelet aggregation, which makes them applicable for the treatment of circulatory system dysfunctions, particularly at the level of the cardiovascular system. The international application was published together with an international search report. |