| abstract |
The compounds of formulas (1A) and (1B), or their pharmaceutically or veterinary acceptable, or pharmaceutically or veterinary acceptable solvates of any of them, where R is C-C-alkyl, substituted by C-C-cycloalkyl, CONRR or N-linked heterocyclic group; (CH) Het or (CH) Ar; R4 is C-C-alkyl; R 5 is C 1 -C 6 -alkyl, possibly substituted by a C 1 -C 5 alkoxy group; R represents SONRR; Each of R and R is independently from H and C, - C-alkyl, optionally substituted by C, - C alkoxy, or together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic group; Together with the nitrogen atom to which they are attached, form a 4-R-piperazinyl group; R 5 is H or C 1 -C 6 alkyl, optionally substituted with OH, C 2 -C 6 -alkoxy or CONH; Het is a possibly substituted C-linked 5- or 6-membered heterocyclic group; Ar is a possibly substituted phenyl; and n is 0 or 1; are potent and selective inhibitors of cGMP PDE5, useful in the treatment of inter alia, erectile dysfunction in men and sexual dysfunction in women. |