| abstract |
The function of glutamate receptors in mammals can be potentiated using an effective amount of a compound of formula (I) R-L-NHSOR, where R represents an unsubstituted or substituted aromatic or heteroaromatic group; R5 is (CC) -alkyl, (CC) -cycloalkyl, (CC) -fluoroalkyl, (CC) -chloroalkyl, (CC) -alkenyl, (CC) -alkoxy- (CC) -alkyl, phenyl, which is unsubstituted or substituted halogen, (CC) -alkyl or (CC) -alkoxy, or a group of the formula RRN, where each of R1 and R2 is independently (CC) -alkyl, or together with the nitrogen atom to which they are attached, form azetidinyl, pyrrolidinyl, piperidinyl morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents (CC) -alkylene chain, unsubstituted or substituted by one or two substituents selected independently, among (CC) -alkyl, aryl- (CC) -alkyl, (CC) -alkenyl, aryl- (CC) -alkenyl and aryl, or two substituents, which, together with the carbon atom or carbon atoms to which they are attached, form a (CC) -carbocyclic ring; and its pharmaceutically acceptable salts. New compounds of formula (I), methods for their preparation and pharmaceutical compositions containing them are also described. The international application was published together with an international search report. |