| abstract |
The compound of formula (I), where n, X, R, R and Q are as defined above, is useful in treating a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, congenital epidermolysis bullosa, sclerite and other diseases characterized by the activity of matrix metalloproteinase, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention can be used in combination therapy with standard nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer. The international application was published along with an international search report. |