| abstract |
The application describes compounds of formula (I *), where R denotes (ness.) Alkoxycarbonyl, R denotes secondary or tertiary (ness.) Alkyl or (ness.) Alkylthio (ness.) Alkyl, denotes phenyl, which is unsubstituted or substituted by one or more (lower) alkoxy radicals, or C-Ccycloalkyl, R denotes phenyl or cyclohexyl, each of which is substituted in the 4th position by an unsaturated heterocyclyl, which is bonded by a ring carbon atom, contains 5-8 ring atoms, contains 1-4 heteroatoms selected from nitrogen, oxygen, sulfur, sulfur in the form of sulfin la (-SO-) and sulfonyl (-SO-), and is not substituted or substituted by (lower) alkyl or phenyl (lower) alkyl, R regardless of R has one of the values specified for R, a R regardless of R denotes (lower. ) alkoxycarbonyl, or a salt thereof, provided that at least one salt-forming group is present. These compounds are inhibitors of retroviral aspartate protease and can be used, for example, in the treatment of AIDS. They have extremely valuable pharmacokinetic properties. The international application was published along with an international search report. |