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filingDate 1997-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1999-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EA-199800464-A1
titleOfInvention SYNERGISTIC IMMUNOSUPRESSOR COMPOSITION CONTAINING 2,2'-BI-1H-PYRROL COMPOUND
abstract A substance containing: (a) an immunosuppressive agent (A) and (b) at least one immunosuppressive 2,2'-bi-1H-pyrrole compound (B), having the formula (I) in which R1 is hydrogen, phenyl, an alkyl group with 1-20 carbon atoms or an alkenyl group with 2-20 carbon atoms, wherein the alkyl and alkenyl groups can be unsubstituted or substituted with one to three substituents, the same or different, independently selected from halogen, alkoxy groups with 1-6 carbon atoms, hydroxy, aryl or aryloxy groups; R 2 is is hydrogen, an alkyl group with 1-6 carbon atoms, a cyano group, a carboxy group, or (C-Salkoxy) carbonyl; R 2 is a halogen, hydroxy group, or an alkoxy group with 1-11 carbon atoms, unsubstituted or substituted with phenyl; -6 carbon atoms or phenyl; each of R 8 and R 8, which are the same or different, independently represent hydrogen, an alkanoyl group with 2-20 carbon atoms, an alkanoyl group with 3-20 carbon atoms, a phenyl group, an alkyl group with 1-20 carbon atoms or alkenyl group with 2- 20 carbon atoms; or two of R, R and R, taken together, form a polymethylene chain with 4 to 12 carbon atoms, which can be unsubstituted or substituted by an alkyl group with 1 to 12 carbon atoms, an alkenyl group with 2 to 12 carbon atoms or an alkylidene group with 1 -12 carbon atoms; or a pharmaceutically acceptable salt thereof; as a combined preparation for simultaneous, separate or sequential use in immunosuppressive therapy; the abovementioned preparation has an increased immunosuppressive activity compared to preparations containing either
priorityDate 1996-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 41.