| abstract |
The claimed compounds, methods of use and methods for preparing inhibitors of factor D complement, including formula I, or a pharmaceutically acceptable salt, or a composition thereof, where R12 or R13 on group A is aryl, heteroaryl or heterocycle (R32). The inhibitors described herein act on factor D and inhibit or regulate the complement cascade at an early and significant point in the alternative complement pathway and reduce the ability of factor D to modulate the classical and lectin complement pathways. The factor D inhibitors described herein are capable of reducing excessive complement activation, which is associated with certain autoimmune, inflammatory and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer. |