abstract |
Provided herein are compounds of formula (IIa1), or a free acid, free base, pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, Ra, Rb and Rc are defined herein, a method of enhancing the inclusion of exon 7 SMN2 in mRNA that is transcribed from the SMN2 gene, and a method for increasing the amount of Smn protein using the claimed compound. |