| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5db10fc7df2cd2c807a46669c77bb690 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-577 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f21a45e5726793507f7e58b39da54d14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a7e26d684c5e9a6344efec17e5a2a6 |
| publicationDate |
2020-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-036483-B1 |
| titleOfInvention |
PEPTIDES CAPABLE OF INDUCING TOLERANCE TO RECOMBINANT FVIII, CONTAINING THEIR COMPOSITION, THEIR APPLICATION AND METHOD FOR TREATING HEMOPHILIA |
| abstract |
The present invention relates to peptides capable of inducing tolerance to recombinant FVIII, capable of binding to an MHC class I or II molecule and being presented to a T cell without additional processing, containing the sequence XXGDNIMVTFRNQASRPYGXX or XXGPRCLTRYYSSFVNMEGXX. The present invention also relates to a composition containing the claimed peptides, to the use of the claimed peptides or composition for suppressing or preventing the production of FVIII inhibiting antibodies in vivo and a corresponding method, as well as to a method for treating hemophilia in a patient, comprising the step of administering to the patient a peptide or composition according to the invention. |
| priorityDate |
2012-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |