| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87a863132c68cf0f62015bbd5d05ab38 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2318-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate |
2014-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94584350883ffc2adea9d87984844f1d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_151fc1d014c9083bf24cb69accc00c37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcd3f97b5383ba1629d34a5533d83a15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4ca730c0714ddce8eaff712a74604db |
| publicationDate |
2020-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-035745-B1 |
| titleOfInvention |
BINDING MOLECULES BASED ON THE TYPE III FIBRONEKTIN DOMAIN WITH INTEGRATED CYSTEINE RESIDUES |
| abstract |
Monospecific and bispecific to EGFR and / or c-Met molecules with inserted cysteine residues containing the FN3 domain, which contain one or more free cysteine amino acids, are obtained by mutagenesis of the nucleotide sequence of the original molecule and replacing one or more amino acid residues with cysteine to encode monospecific or bispecific molecules with inserted cysteine residues containing the FN3 domain; the expression of molecules with inserted cysteine residues containing the FN3 domain; and recovering the cysteine-embedded molecule containing the FN3 domain. An isolated monospecific or bispecific molecule with introduced cysteine containing the FN3 domain can be covalently linked to a detector label or drug fragment and used for therapeutic purposes. |
| priorityDate |
2013-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |