| abstract |
- Hairpin peptidomimetics of general formula (I), cyclo [PPPPPPPPPPPPTT] and their pharmaceutically acceptable salts, in which PP, T and T are elements, as defined in the description and claims, having a wide spectrum of antimicrobial activity against gram-negative bacteria, for example, activity to inhibit growth or kill microorganisms such as Klebsiella pneumoniae and / or Acinetobacter baumannii, and / or Escherichia coli. They can be used as medicines for treating or preventing infections, or as disinfectants for foods, cosmetics, medicines, or other materials containing nutrients. These peptidomimetics can be obtained using a method based on a mixed strategy of solid-phase synthesis and solution synthesis. |