| abstract |
The invention relates to compounds of the formula I or their pharmaceutically acceptable salts, in which R, R, L, L, X, Y and Y 'are described in the present invention. The compounds of the invention are N-alkylaryl-5-hydroxyaryloctadihydrocyclopent [c] pyrrole negative allosteric modulators of NR2B receptors and may be useful in the treatment of neurological disease, abnormal brain function and / or emotional disturbance. The invention also relates to a pharmaceutical composition for modulating NR2B receptors, a method for modulating NR2B receptors in a subject, and a method for treating these diseases. |