| abstract |
- Hairpin peptidomimetics of general formula (I), cyclo [PPPPPPPPPPPPTT], and their pharmaceutically acceptable salts, in which PP, T and T, are elements, as defined in the description and claims, have antimicrobial activity against gram-negative bacteria, for example, activity inhibit the growth or kill microorganisms such as Klebsiella pneumoniae and / or Acinetobacter baumannii and / or Escherichia coli. They can be used as medicines for treating or preventing an infection, or as disinfectants for foods, cosmetics, medicines, or other materials containing nutrients. These peptidomimetics can be obtained using a method based on a mixed strategy of solid-phase synthesis and solution synthesis. |