| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec21f63ed71a43e80df5c8d6e738a4ff |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2013
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 |
| filingDate |
2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20f1ed8cd2eebf07ecc815ec42086c6e |
| publicationDate |
2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-034925-B1 |
| titleOfInvention |
MODIFIED OPTIONS OF IL-2, WHICH SELECTIVELY ACTIVATE REGULATORY T-CELLS, FOR TREATMENT OF AUTOIMMUNE DISEASES |
| abstract |
The invention provides a novel IL-2 protein with selective agonistic activity against regulatory T cells and with an additional amino acid substitution, which provides the opportunity for chemical conjugation with polyethylene glycol (PEG), which lengthens the half-life from the bloodstream compared to just one IL-2 selective agonist. A preferred embodiment of the IL-2 selective agonist is IL2 / N88R / C125S / D109C. |
| priorityDate |
2014-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |