abstract |
The invention relates to compounds acting as selective antagonists of 8 members of the subfamily M of the cation channel of the transient receptor potential (TRPM8) and having the formula (I) These compounds are used in the treatment of diseases associated with TRPM8 activity, such as pain, inflammation, ischemia, neurodegeneration, stroke, mental disorders, pruritus, irritable bowel diseases caused by colds and / or exacerbated respiratory disorders and urological disorders. |