http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-034347-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-00 |
| filingDate | 2012-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acab947d5348171b33f8e2686e3cc956 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba7ad7da9ec46c43994917256a0c78ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c8991ffaedeca802c188684557c6290 |
| publicationDate | 2020-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-034347-B1 |
| titleOfInvention | METHOD FOR VIRUS INACTIVATION AT OBTAINING ANTIBODIES |
| abstract | The invention provides a method for inactivating a virus in the production of a therapeutic antibody, the method comprising: (a) providing a sample containing a therapeutic antibody, said sample being an effluent after the antibody purification step, and it is known or suspected that said sample contains a virus; (b) introducing a protective agent into the effluent to form a stabilized mixture, the protective agent comprising tyrosine, tryptophan, or a combination thereof; (c) measuring the absorption of the stabilized mixture using an integrated absorption spectroscope, where the absorption of the stabilized mixture is measured at a wavelength of 254 nm using an integrated absorption spectroscope; (d) passing the stabilized mixture through a device, the configuration of which allows continuous exposure to UV radiation so that the target dose of UV radiation at which the virus is inactivated is delivered to the mixture; (e) moreover, on the basis of the absorption estimate, the correction of the effect of UV radiation is carried out in such a way that the target dose of UV radiation is continuously delivered to the stabilized mixture passing through the specified device, while steps (c), (d) and (e) are carried out in in real time as an automated feedback element, while delivering the target dose is adjusted, taking into account the varying absorption capacity of the stabilized mixture, to maintain the constant target dose by the formula dose ~ (P / Q) exp (-al) = (P / Q) exp (-al), where a is the absorption capacity of the solution, l is the path length along the annular gaps, P is the output power of the lamp, Q is the volumetric flow rate of the mixture with absorption capacity = a, P and Q are power and flow rate reference mixture with absorbency = a. The proposed method can be implemented on any scale. |
| priorityDate | 2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.