| abstract |
The invention relates to new derivatives of 5,6-dihydroimidazo [1,5-a] pyrazin-3 (2H) -one as inhibitors of beta-secretase, also known as an amyloid cleaving enzyme at the beta site, BACE, in particular, BACE1 and / or BACE2 (where BACE1, also known as Asp2 or memapsin 2, and BACE2, also known as Asp1, memapsin 1 or DRAP). The present invention also relates to pharmaceutical compositions containing such compounds, to methods for producing such compounds and compositions, and to the use of such compounds and compositions for preventing and treating disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment , senile dementia, dementia, Levi calf dementia, Down syndrome, dementia associated with stroke, dementia associated with Parkinson’s disease, dementia of Alzheimer's type, demen tion associated with beta-amyloid accumulation, age-related macular dystrophy, type 2 diabetes and other metabolic disorders. |