| abstract |
Antibodies and antigen-binding antibody fragments that bind GCC are described. Antibodies bind to the extracellular domain of GCC and may be internalized. In some embodiments, the antibodies are humanized, chimeric, or human. Also described are nucleic acids and vectors encoding antibodies or parts thereof, recombinant cells that contain nucleic acids, and compositions containing antibodies or antigen-binding fragments. The invention also provides therapeutic and diagnostic methods using the antibodies and antigen-binding fragments disclosed in this application. |