| abstract |
The invention relates to an isolated antibody that specifically binds to cadherin-17 with high affinity. It also describes nucleic acid molecules that encode antibodies to cadherin-17, expression vectors, and host cells. The objects of the present invention are also an immunoconjugate for treating or preventing diseases associated with target cells that express cadherin-17, and the corresponding pharmaceutical composition, which include antibodies to cadherin-17. In addition, it relates to methods for producing cadherin-17 and a method for treating or preventing diseases associated with target cells that express cadherin-17, including various types of cancer, including colorectal cancer. |