| abstract |
The invention relates to a granulate, a capsule, a method for their preparation and use for treating a fibrous disease or for inhibiting the action of cytokines in a patient suffering from a cytokine mediated disorder, where said capsule and granulate contain the pharmaceutical composition 5-methyl-1-phenyl-2- (1H ) -pyridone, in which the specified pharmaceutical composition contains 5-30 wt.% pharmaceutically acceptable excipients and 70-95% 5-methyl-1-phenyl-2- (1H) -pyridone, where pharmaceutically acceptable excipients contain 2-30 wt. % pharmaceutical positions agent and coupling agent of binder comprises povidone, and 1-4% by weight of said granules and capsules may be povidone. Such a granulate and capsule support the desired pharmacokinetic response in a patient. In addition, methods have been proposed for treating fibrotic diseases and other cytokine-mediated disorders by administering pyrphenidone capsules to a patient in need. |