| abstract |
The subject of the present invention is a comronization product for the preparation of a pharmaceutical composition containing an active substance selected from the group consisting of selective progesterone receptor modulators of formula (Ia) in which R1 is —OH, alkoxy C — C 1 —C (O) R; R4 is -OH, alkoxy C-C, alkynyl C-C, alkenyl C-C, or OC (O) -R, where R and R are independently selected from the alkyl group C-C and alkoxy of C-C; R1 is -NRR, where R1 and R3 are independently -H or C -C алки alkyl; —CH = N — O — R, where R stands for —H, or —C (O) —X — R, where R is C-C1-6 alkyl, and X is O, NH, or S; or —C (O) R, where R 4 is C 1 -C 6 alkyl; and a polymeric excipient based on N-vinyl-2-pyrrolidone. The invention also relates to a pharmaceutical composition comprising said somicronization product and their therapeutic use. |