| abstract |
The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorphic form, including all their tautomers and stereoisomers, in which R, R, R, R and R are as defined in the invention, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues with the formation of pyroglutamic acid (5-oxoprolyl, pGlu *) with the release of ammonia and the intramolecular cyclization of N-terminal glutamine residues with the formation of pyroglutamic acid with the release of water. |