| abstract |
The invention provides pyridine and pyrazine derivatives, which restore or enhance the function of the wild type mutant MBTP and / or MBTP for the treatment of cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory infections, lung carcinoma, xerostomia and dry keratoconjunctivitis or constipation (IBS, IBD caused by an opioid). The invention also describes pharmaceutical compositions containing such derivatives. |