| abstract |
Described in some embodiments, the implementation of solid oral dosage form containing a variety of particles, each particle contains: (i) a core containing the first active agent; (ii) a coating containing a second active agent, layered on the core; and (iii) a material that is sensitive to acidic pH, layered on the coated core; however, the dosage form releases at least about 70% of the second active agent within 45 minutes, which is determined using in vitro dissolution in the USP 2 apparatus (paddle) at 50 rpm in 500 ml of 0.1 N HCl at 37 ° C. |