| abstract |
The invention relates to formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R and R-R are described in the present invention. The present invention also relates to compositions containing a compound of formula (I), and to the use of these compounds in inhibiting IDH mutant proteins with non-morphic activity. The present invention also relates to the use of a compound of formula (I) in the treatment of diseases or disorders associated with these mutant IDH proteins, including, but not limited to, diseases caused by cell proliferation, such as cancer. |