http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-027910-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_282d8844066f5f683bc2463742373508 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2014-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c354ff6fc62209a5c2aa54f75808343c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32ed088bd4384fd59d083b9a09a81c3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237bcaf6d261453670ebd99a87743b2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f234daff534c0918e2b836f116bfcee |
| publicationDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-027910-B1 |
| titleOfInvention | Pyrrolobenzodiazepines and their conjugates |
| abstract | Conjugated compounds of formula (A): or, in the case where one of the R and R is H, the other is selected from nitrile and C1-6 alkyl ether; R5 and R4 are independently selected from H, R, OH, OR, SH, SR, NH, NHR, NRR ', NO, MeSn and halogen; R is independently selected from H, R, OH, OR, SH, SR, NH, NHR, NRR ', NO, MeSn, and halogen; Y is selected from formulas (A1) to (A6): L is a linker attached to a cell-binding agent; CBA is a cell binding agent; n is an integer selected from the range 0-48; R1 is a C1-6 alkylene group; or (a) R 5 is H and R 1 is OH, OR, where R 2 is C 1-6 alkyl; or (b) R and R form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are attached; or (c) R5 is H and R4 is OSOM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; each of R and R ′ is independently selected from an optionally substituted C1-6 alkyl, Superheroclyl and Saryl groups, and optionally with respect to the group NRR ′, R and R ′ together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5-, 6 - or a 7-membered heterocyclic ring; R, R, R, R, R and R are as defined for R, R, R, R, R and R, respectively; Z is CH or N; T and T 'are independently selected from a simple bond or Ckylene, in whose carbon chain one or more heteroatoms can be included, for example O, S, N (H), NMe, provided that the number of atoms in the shortest chain between X and X 'is from 3 to 12 atoms; and X and X 'are independently selected from O, S, and N (H). |
| priorityDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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