http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-027800-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4eb6dbca25e5f9459a6c5f592728c787 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
| filingDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c65564c7ee79d85984b80cecfe13870 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5247a02d81e8d80ee1ee80004de3ddc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8b541b3ea9b7eb4371ec97e2a565377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc08765baa0ff6286a189e6b740c0529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_285437596fb05f311b025b3ba81baba3 |
| publicationDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-027800-B1 |
| titleOfInvention | DERIVATIVES 3-PHENYLISOHINOLIN-1 (2H) -ONE AS PARP-1 INHIBITORS |
| abstract | The invention provides substituted 3-phenylisoquinolin-1 (2H) -one derivatives selected from the group consisting of 4- (2-aminoethoxy) -3- (4-bromophenyl) -7-fluoro-2H-isoquinolin-1-one, 4- (2-aminoethoxy) -7-fluoro-3- (3-trifluoromethylphenyl) -2H-isoquinolin-1-one, 4- (2-aminoethoxy) -3- (3-bromo-4-morpholin-4-ylphenyl ) -7-fluoro-2H-isoquinolin-1-one, 4- (2-aminoethoxy) -3- (4-chlorophenyl) -7-fluoro-2H-isoquinolin-1-one, 4- (2-aminoethoxy) - 7-fluoro-3- (4-fluorophenyl) -2H-isoquinolin-1-one, 3- [4- (2-aminoethoxy) -7-fluoro-1-oxo-1,2-dihydroisoquinolin-3-yl] benzonitrile , 4- (2-aminoethoxy) -3- (4-bromophenyl) -7,8-difluoro-2H-isoquinolin-1-one, 4- (2-aminoeth xi) -3- (4-chloro-3-methylphenyl) -7-fluoro-2H-isoquinolin-1-one, 4- (2-aminoethoxy) -3- (3,4-dichlorophenyl) -7-fluoro-2H -isoquinolin-1-one and 4- (2-aminoethoxy) -7-fluoro-3- (3-fluoro-4-methoxyphenyl) -2H-isoquinolin-1-one, which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 for poly (ADP-ribose) polymerase PARP-2. Therefore, the compounds of the present invention are useful in the treatment of diseases such as malignant tumors, cardiovascular diseases, damage to the central nervous system and various forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions containing these compounds, and methods for treating diseases using pharmaceutical compositions containing these compounds. |
| priorityDate | 2011-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 353.