| abstract |
The invention relates to new substituted 3,4-dihydro-2H-pyrido [1,2-a] pyrazin-1,6-dione derivative of the formula (I) where R, R, R, R, R, Z and X have the meaning, as defined in the claims. Compounds in accordance with the invention are applicable as modulators of gamma secretase. The invention further relates to methods for the preparation of such new compounds, to pharmaceutical compositions containing said compounds as an active ingredient, as well as to the use of said compounds as a medicine. |